A multi-scale analysis model which can reflect thermal-mechanical damage effects, such as ablation, pyrolysis and delamination within layers in the high-power continuous-wave laser irradiation of carbon fiber reinforced polymer (CFRP) laminates is built. The pyrolysis kinetic equations of fibers and matrices are derived from the meso-scale analysis, and the pyrolysis kinetic parameters are obtained from the thermo-gravimetric analysis, thereafter the macroscopic thermal-physical and mechanical property parameters of CFRP laminates are obtained. Based on the cohesive model, an analysis model is built to describe the laser induced delamination behavior within layers. Meanwhile, a thermal-resistance model is also proposed and built to describe the attenuation of thermal energy due to pyrolysis and delamination within layers. By combining the thermal-mechanical property parameters obtained from the multi-scale model with the thermal-mechanical numerical model, the ablation, pyrolysis and delamination within layers of CFRP laminates irradiated by high-power continuous-wave lasers can be simulated. The numerical results show good agreement with the experimental data.