In order to improve the surface hardness and wear reduction of TC4 alloy, Fe60-TiO2 composite coatings with different proportions were prepared on the surface of TC4 plate by using several groups of process parameters (different power and different TiO2 powder content). The macroscopic morphology, surface Vickers hardness, and wear reduction property of the cladding layer were analyzed. The results show that when the laser power is 500W and the mass fraction of TiO2 is 0.10, the surface of the cladding layer is smooth. According to the X-ray diffraction analysis, many Ti compounds are formed in the cladding layer, which is very beneficial to improve the hardness and wear reduction of the cladding layer. The hardness of the cladding layer is about 2.5 times higher than that of the substrate. The average friction coefficient of the cladding layer is about 0.46. The results have a certain guiding effect on the hardness and wear reduction process parameters of Fe based composite coating on TC4 titanium alloy surface.