Firstly, the relationship among the interface, the density difference and the interfacial tension is analysed with the Laplace equation. Then, as for the combination and selection of materials, we use a new ionic conductive liquid and four kinds of common insulating liquid so as to obtain four combinations of the conductive liquid and the insulating liquids according to density difference. Finally, by simulation, we calculate the corresponding equations and analyse the imaging quality of the liquid lens with aspheric interface. It is concluded that the imaging quality is improved when the liquid lens with aspheric interface is compared to a liquid lens with spherical interface, but it has no positive correlation with the degree of the asphericity and the imaging quality.