The laser anti-UAV system is a direct energy system that uses high-power laser energy to converge onto the target for destruction. The current demand for anti-UAV systems in portable task scenarios is increasing. Due to the weight and volume of high-power laser systems, it is not easy to execute portable task scenarios. This article presents the system design of a portable laser anti-UAV system and research on a portable laser anti-UAV system that can be carried by teams and disassembled. This article adopts a design method that combines lightweight and compact spindle tracking with large stroke precision tracking, and based on an air-cooled heat dissipation laser, realizes the design of a 2000 W portable laser anti-UAV system. In order to verify the performance of the portable system, static damage experiments, tracking experiments, dynamic strike experiments, and portable performance tests were conducted. A 2000 W portable laser system with a total weight of less than 160 kg, capable of disassembling into four single modules weighing less than 40 kilograms, suitable for two people to carry and transport. In the field experiment, the time to penetrate the 2 mm thick stainless steel plate at a distance of 300 m was 12 s, respectively. The dynamic strike UAV can be shot down in 9 s. The experimental results show that the designed laser anti-UAV system has portable performance and can be applied to the anti-UAV task scenario.