Laser cleaning technology was used to clean the surface of stainless steel, and the influence of dif-ferent laser power (300 W, 400 W, 500 W) on cleaning effect was studied. The surface morphology and composi-tion distribution of stainless steel were analyzed by SEM and EDS. The surface roughness and cleaning thick-ness were detected by White Light Interferometer. The results show that, with the increase of laser power, the ox-ide of stainless steel decomposes and flakes gradually, and the cleaning thickness keeps deepening and reach-es 50 μm at 500 W, which causes partial damage to the matrix. The roughness value decreases firstly and then increases. It reaches a minimum value of 0.38 μm at 400 W. Laser cleaning threshold is approximately 3.96×10³W/cm², and damage threshold is about 5.52×10³W/cm². The best laser cleaning effect of stainless steel is ob-tained when the power is 400 W.