In this study, a magnetic metal-organic framework amyloid fibril (M-UiO-66-NH₂/AF) aerogel was synthesized for the efficient adsorption of lutetium-177 from nuclear medicine wastewater. The morphology, structure, and composition of the aerogel were characterized comprehensively using atomic force microscopy, transmission electron microscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, vibrating sample magnetometry, and physical adsorption analysis. The results showed that the aerogel possesses a uniform and highly porous structure, is ultralight yet robust, and has a density of approximately 30 mg/?cm³. It afforded a maximum absorption rate of 92% for Lu-DOTA-TATE and reached adsorption equilibrium within 60 min. Its adsorption kinetics was consistent with the pseudo-second-order model, wheras its adsorption isotherm data conformed to the Langmuir model, with a maximum adsorption capacity of 0.37 mg/g.