The correlation between mental health and myopia in children and adolescents was explored in order to provide scientific reference for the intervention of mental health in children and adolescents. The results showed that there was a high correlation between myopia and mental health of children and adolescents, the degree of myopia was directly proportional to the degree of anxiety and depression in children and adolescents, and myopia also directly led to a significant decline in the quality of life of children and adolescents. In addition, the prevalence and degree of myopia were also related to personalities, and people with introverted and neurotic personalities were more likely to suffer from myopia.