Laser cladding of powder mixture containing titanium, aluminum, niobium, chromium, carbon and other elements have been conducted on Ti-6Al-4V substrate in order to synthesize titanium aluminides matrix composite coatings reinforced by in-situ titanium carbide particles. Primary analysis of morphology, microstructure, composition, phase structure and microhardness of the coatings had been performed. The results revealed that the microstructure of coatings obtained here can be characterized as γ-TiAl grains+γ-TiAl/α2-Ti3Al lamellas+carbide particles. The γ-TiAl grains exhibit equivalent diameter of approximately one micron. The even distance of lamellas is below 500 nm. The carbide particles exhibit a stick length of several microns and distribute uniformly throughout the coating.