Radiotherapy is one of the conventional treatments of tumor. However, radiation-induced metastasis usually re-sults in the poor clinical outcome of radiotherapy. Tumor angiogenesis is tightly related to its metastasis and the combined administration of anti-angiogenetic drugs with radiotherapy e.ectively improves the prognosis of tumor radiotherapy, there-fore, studies on radiation-related angiogenesis are of practical signi.cance. The purpose of this review is to summarize the re-cent research progress on tumor angiogenesis related to radiotherapy and to provide a considerable reference for developing medicine targeting on angiogenesis and improving the clinical outcome of radiotherapy.