To address the excessive data volume issue in digitally-driven silicon-based OLED (Organic Light Emitting Diode) microdisplays under high resolution, high grayscale, and high refresh rate conditions, this study proposes a low-power dynamic-comparison interface circuit for 2k×2k microdisplays. Currently, low-power interfaces predominantly employ high-speed low-voltage differential signaling (LVDS) transmission schemes, where the analog comparators in the receiver end exhibit significant static power consumption. The proposed circuit employs dynamic comparison techniques for receiving both data and control signals, effectively reducing overall power consumption. Experimental results based on 110 nm process demonstrate that the receiver achieves correct data acquisition at 1.2 V operating voltage with 100 mV input signal swing and 1.25 GHz operating frequency. Notably, the single-channel dynamic comparison receiver consumes only 160.7 μW, representing a 29.4% reduction compared to conventional receiver circuits, while the total system power consumption is merely 4.01 mW. This dynamic-comparison interface circuit provides an innovative design solution for future digital driving circuits with increasingly demanding requirements, offering significant improvements in power efficiency without compromising performance.