Cell Research, Volume. 35, Issue 8, 539(2025)

SPO11 cuts!

Hariri Sara and Hunter Neil

During meiosis, SPO11-catalyzed DNA double-strand breaks (DSBs) initiate homologous recombination, which is essential for accurate chromosome segregation and enhances genome diversification. 28 years after its discovery, three new studies report the reconstitution of SPO11-catalyzed DSB formation in vitro.

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Hariri Sara, Hunter Neil. SPO11 cuts![J]. Cell Research, 2025, 35(8): 539

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Received: --

Accepted: Aug. 26, 2025

Published Online: Aug. 26, 2025

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DOI:10.1038/s41422-025-01093-9

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