In response to the reliability requirements of aluminum alloy wheels for a certain family car，a three-dimensional model of the wheel hub is established using CATIA software. The wheel hub is meshed and simulated using ANSA software，and the natural frequencies and modes of the wheel hub are calculated using post-processing software META. The reliability of the wheel hub design is quantitatively evaluated through the modal separation margin（MSM）index. The calculation results show that the natural frequency of the wheel hub is 383.3 Hz，significantly higher than the excitation frequency of flat road surfaces，uneven road surfaces，and the highest vibration frequency of the engine. The MSM of the wheel hub is 56.5%，far exceeding the minimum safety threshold，effectively avoiding the risk of resonance with adjacent components. The designed wheel hub has high reliability under complex working conditions.