Fe-VOx/SAPO-34 and Fe-VOx/TiO2 catalysts were prepared by impregnation method to explore the catalytic activity and alkali metal resistance of SAPO-34 molecular sieve and TiO2 supported iron vanadium-based oxides. The catalysts were characterized by means of XRD, XPS, NH3-TPD, H2-TPR and in-situ DRIFTs. The results show that: the specific pore structure and stable skeleton in SAPO-34 molecular sieve are conducive to the uniform dispersion of active components on the carrier and reduce the physical coverage of alkali metals on the surface active centers; at the same time, the rich acid sites can be used as alkali metal capture sites to protect the active center on the catalyst surface and ensure the normal adsorption reaction process of the catalyst, so that Fe-VOx/SAPO-34 shows good alkali metal resistance.