In this paper, the curing method was explored that the arsenic slag, which was associated in the non-ferrous metal smelting process cured by high borosilicate glass matrix, and the content of arsenic in the prepared high borosilicate glass samples were determined by EDS. High borosilicate glass with different amount of arsenic and different phase regions were measured and characterized by acetic acid method and sulfuric acid method,respectively. The results showed that the high borosilicate glass had a good effect on curing arsenic, and the leached amount of arsenic depended greatly on the specific surface area of the glass.