The CuO/BiVO₄ heterojunction catalyst responsive to visible light was prepared using the impregnation method. This catalyst was applied to the photocatalytic reduction process for the removal of U（Ⅵ） from aqueous solutions， and a systematic investigation was conducted to examine the influence of various reaction conditions on its photocatalytic performance. The synthesized samples were characterized by X-ray photoelectron spectroscopy （XPS）， X-ray diffraction （XRD）， and scanning electron microscope （SEM）. Using U（Ⅵ） solution as the reactant， the influence of solution pH and sample dosage on the photocatalytic reduction activity of the prepared samples were investigated in this paper. The results show that under the conditions of a solution pH value of 5.5 and a photocatalyst dosage of 0.8 g/L， CuO/BiVO₄ photocatalyst demonstrates a high catalytic reduction efficiency for the removal of U（Ⅵ） from solution， with the removal rate reaching up to 94% after 120 min. This study aims to explore the synthesis of novel heterojunction catalyst materials to address the issue of low photocatalytic efficiency in single-phase photocatalytic materials， thereby providing new insights and directions for research on the photocatalytic removal of U（Ⅵ） from solutions.