Objective: To observe the effectiveness of treatment of xanthelasma palpebrarum with ultrapulsed-CO₂ laser. Methods: 36 patients of Xanthelasma Palpebrarum (78 periorbital xanthelasmas) were treated with ultra-pulsed CO2 laser (maximal pulse energy 500J/impulse) irradiating on lesions. Results: All lesions could be removed completely with a single laser treatment. After 1 -10 months follow-up time, no visible scarring was observed. 4 patients (11. 11%) developed a recurrence of xanthelasma. Conclusion: The ultrapulsed CO2 laser is an effective and safe therapeutic alternative to all the other surgical procedures.