Single MoSi2 cladding is prepared by CO2 laser with a spot diameter of about 3 mm. The main phase of long dendrite in the cladding layer is (Fe,Si)2Mo, as revealed by X-ray diffraction (XRD) and scanning electron microscope (SEM) detection. The interdendritic phase is mainly α-Fe and Fe2Si. Micro-hardness of the coating is maintained at about 700 HV. The spot is shaped to a rectangle with the size of 2 mm×6 mm, and the cladding of Ni/MoSi2 mixed powder is then performed. It is found that as the Ni-based alloy increases, the cracks are significantly reduced, and the critical mass ratio of Ni and MoSi2 is 37. By calculating thermal stress and dilution ratio, it is proved that broadband laser cladding can be appropriate to reduce the thermal tensile stress and dilution rate. Finally, XRD and energy dispersive spectrometry (EDS) are used to detect the Ni/MoSi2 cladding and the main phases of high Mo dendrite are found to be MoSi2 and NiMo. The average micro-hardness is 750 HV and the maximum microhardness is 861.9 HV, present in the dendrite of coating, achieving the purpose of improving substrate physical properties.