To improve heat-sink performance of the high-power solid-state laser, the refrigeration-spray cooling system was designed by combining the refrigeration cycle and the spray cooling system, and R600a was used as the coolant. The effects of heat flux, evaporation pressure, and nozzle inlet pressure on the heat transfer performance were analyzed by experiment. The heat-sink surface temperature could be kept below 60 ℃ at 123 W/cm2 heat flux. The heat transfer coefficient was obtained up to 25000 W/(m2·K) when the nozzle inlet pressure and the evaporation pressure were 350 and 185 kPa, respectively. And standard deviation of the surface temperature was only 2.5 ℃ when the heat flux was 130 W/cm2. The above results show that the system can get a lower surface temperature, more uniform surface temperature distribution and higher heat transfer coefficient, which can meet the heat removal demand for high-power solid-state lasers.