Based on the technology of the JAS film TFT-LCD pixel structure, the pixel voltage crosstalk effects of different panel inversion modes on the two kinds of JAS and non-JAS module were compared by analyzing the experiments. The results show that crosstalk has nearly no effect on the pixel voltage of the non-JAS under different inversion modes. The solution of the color crosstalk problem caused by the parasitic capacitance (Csd) between the data line and the TFT drain electrode was proposed. These results have some guiding effect to solve the pixel voltage crosstalk problem and the pixel structure design of the large size and high resolution TFT-LCD products.