Conventional titanium alloys are prone to ignition under conditions of high temperature, pressure, and high-speed airflow, resulting in rapid spread and causing "titanium fire" failures, which significantly limit their application in aero-engines. This study aims to prevent "titanium fire" accidents by preparing a Ti-Cu burn-resistant alloy layer on the surface of Ti6Al4V titanium alloy using laser alloying technology. The morphology of the Ti-Cu burn-resistant alloyed layer was analyzed by optical microscope and SEM, and the micro-hardness of the Ti-Cu burn-resistant alloyed layer was analyzed by Vickers micro-hardness instrument, and finally the burn-resistant behavior of the modified layer was studied by high temperature friction wear testing machine. A continuous dense alloying layer can be formed on the surface of the titanium alloy by the laser alloying technology, The thickness of the Ti-Cu burn-resistant alloyed layer is about 220 μm; The hardness of the modified layer is gradient changes with the depth of alloyed layer, The highest hardness of the Ti-Cu burn-resistant alloyed layer reached 616 HV which is 1.61 times compared with that of the Ti6Al4V titanium alloy. At 600 ℃, The friction coefficient of the Ti6Al4V alloy substrate (0.47) and the Ti-Cu burn-resistant alloyed layer (0.46) are roughly same. At 600 ℃, The main wear mode of both the Ti6Al4V titanium alloy and the Ti-Cu burn-resistant alloyed layer is a mixture of adhesion and abrasion. The wear width of Ti6Al4V titanium alloy is 2.14 times compared with that of Ti-Cu burn-resistant alloyed layer, and the wear volume and wear rate of Ti6Al4V titanium alloy are 5.5 times compared with those of the modified layer.