An experimental study on the laser welding of glass/stainless-steel and glass/titanium-alloy materials is conducted, and the differences in fracture morphology, sectional shape, and weld phase of welding parts are emphatically analyzed. The results indicate that, as for the glass/stainless-steel and glass/titanium-alloy materials, their welding mechanisms are similar, and the mosaic structure in the welds of glass/metal material and the adhesion substance at the interface play major roles in connecting these two kind of materials. The linear expansion coefficient of glass/titanium-alloy material is small, which is the main reason why the breaking strength of welding parts between titanium-alloy and glass is high. Chemical adhesion takes place in laser welding of glass/titanium-alloy material, which produces Ti5Si3 compound. In contrast, as for the glass/stainless-steel material, mechanical mixing occurs mainly.