Optimal selection of protective coatings for localized corrosion of load-bearing quick release locks was carried out. Using COMSOL software, a galvanic corrosion model for three components of a load-bearing quick release lock was established based on the physical field of secondary current distribution. The electrochemical parameters of different coatings were measured through electrochemical experiments and imported into COMSOL. The anode current density and corrosion depth of each component were compared, and the optimal protection scheme was determined: the spherical base was Ti-6Al-4V anodized+MoS₂ coating; the closing nut was passivated with 17-4PH and coated with MoS₂; the nut support was 17-7PH passivated+MoS₂ coated. The salt spray test results confirmed that the corrosion of the load-bearing quick release lock was mainly caused by galvanic corrosion due to localized water accumulation, and the corrosion rate in the localized water accumulation area was higher than that in other areas. Through COMSOL software simulation, new ideas can be provided for coating optimization of structural components, saving time and economic costs.