This paper aims to analyze the variation pattern of irrigation water use in the Huang-Huai-Hai Plain and its relationship with drought. Based on the irrigation water consumption and withdrawal data, GRACE data and scPDSI data, the relationship between irrigation water use and drought in the Huang-Huai-Hai Plain was analyzed in this paper. The results showed that (1) irrigation water consumption accounts for about one-third of the water withdrawal. The irrigation water use in the southern part of Hebei province, Henan and Shandong province is higher than that of other regions. Irrigation water withdrawal in the Huang-Huai-Hai Plain increased from 2003 to 2014, with a rate of about 37 mm/month. (2) The meteorological condition tended to be arid, and there was a significant nonlinear correlation between scPDSI and the number of cells with positive irrigation water withdrawal anomaly (R2=0.60), especially from August to December. (3) The obvious decrease of precipitation led to occurrence of drought events. Therefore, irrigation water withdrawal was increased to ensure grain production. This indicates that drought is a major cause for increased irrigation water use in the Huang-Huai-Hai Plain and exacerbates the terrestrial water storage deficit.