This study focuses on the adaptability of urban green and gray infrastructure in Golmud City, and conducts simulation analysis based on the InfoWorks ICM model and multi-objective optimization NSGA-II algorithm. The simulation results show that the proportion of green infrastructure configuration in drainage zone Ⅱ is as following: sunken greenbelt (8.15%) > permeable pavement (7.22%) > grassed swales (1.56%), and the reconstruction proportion of gray infrastructure irrigation canals is 48.20%. The configuration proportion of green-gray infrastructure in the drainage zone Ⅱ is relatively high in the middle and lower reaches of the drainage zone, which can achieve better results. Based on the research results, targeted suggestions are put forward for the construction of green-gray infrastructure in Golmud City.