The piezoelectric ceramic driving power is a key component of the micro-displacement system. In order to meet the system's application requirements for high stability and high precision, a new drive power supply based on the PB58 high-voltage operational amplifier is designed in this paper. The STM32 microcontroller is used to control the input signal, receive and monitor the output signal status. The combination of feedback zero point compensation and noise gain compensation greatly improves the stability of the amplifier circuit. A system is set up and the testing and analysis were conducted. Ultimately, it was proven that the power supply system has the excellent characteristics of high stability, fast response speed, and high output power.