As the core course of optoelectronic undergraduates, Quantum Mechanics plays an extremely important role in the subsequent study and mastery of professional knowledge. According to the teaching summary, the pre-courses have very significant impacts on students for learning Quantum Mechanics. It is necessary to carry out further quantitative analysis and evaluation of the impacts. In this paper, based on factor analysis method and the scores of previous courses and Quantum Mechanics, five course groups composed of previous courses are formed. According to the grey absolute correlation degree, we analyze the significant factors of influence on Quantum Mechanics by which pre-course. Finally, based on the multiple linear regression method, we analyze the correlation between the pre-course and Quantum Mechanics, and summarizes the optimization suggestions for the pre-course setting and teaching based on the analysis results.