The OCT is used to preliminary explore the effect of moxibustion on epidermal microcirculation at different points on the meridian. Three moxibustion experiments were carried out for each healthy volunteer, and a total of 30 experimental data were obtained. Each group performed 10 measurements on four observation points, and a total of 1200 data were obtained. Based on the imaging characteristics of OCT signals and the optical characteristic parameters in tissue optics, the backscattered signal interval at the acupoint depth of 0.4~1.0mm is fitted to obtain the light attenuation coefficient of the acupoint skin. The results show that compared with the skin light attenuation coefficient in the natural state, the skin light attenuation coefficient of acupuncture points increases by about 40% within 30 minutes after moxibustion, and the backscattered signal intensity of other acupoints on the meridian point where the moxibustion point was located is significantly reduced. This phenomenon is not observed at non-acupoint control points near the meridians and at other control points on the meridians. The results show that the effect of moxibustion on acupoint skin microcirculation can be transmitted to other acupuncture points through the channels of meridians using OCT. This phenomenon has certain clinical significance and further extends the scope of application of traditional OCT.