The original stope benches of Dahuangshan Open-pit Mine were in disarray, with pumice between benchs and steep slope conditions. Following blasting operations, a crushing system was introduced to improve rock fragmentation efficiency, significantly increasing potential safety risks near high and steep slopes. This study researched safe blasting techniques and protective measures for slopes in open-pit mines to ensure slope safety during blasting construction. Active protection methods were proposed, including limiting instantaneous charge to 200 kg, aligning the blasting direction parallel to the slope, and preserving approximately 5 m of rock wall along the slope edge. Protective infrastructure was enhanced by installing two protective nets on a cleaning platform mid-slope, excavating a 7 m-deep and 20 m-wide stone protection ditch at the foot of the slope, building a 2 m-high stone protection wall using crushed stones outside of the ditch, and erecting a 2 m-high isolation net outside the protection wall. These safety measures were complemented by auxiliary monitoring methods to enhance the safety of blasting operations and protect the crushing system. Field inspections confirmed that the construction methods effectively ensured the stability of the high-steep slopes and minimized risks during blasting.