By means of simulated annealing genetic algorithm, frequency-response characteristics of nonuniform-delay-time microwave photon filter with full/non positive coefficients are analyzed. And the window-function method is applied at the same time. Simulation results show that the more taps lead to better performance at full-positive symmetric coefficient filter. In the case of low-pass filter, full-positive coefficients limit largely factor on the span of transfer function, the characteristics improvement of non full-positive coefficients filter is obvious. At the same cut-off frequency, the optimal performance of simulated annealing genetic algorithm is slightly better than that of the window-function method. Once limiting the cut-off frequency of pass-band and stop-band, and relaxing the requirements of the transition zone, the advantages of simulated annealing genetic algorithm are much more obvious.