In order to quickly and easily prepare micro-nano structures on the surface of nickel-based alloys to achieve super-hydrophobicity, femtosecond laser processing and modification with fluorosilane were used to successfully achieve super-hydrophobicity on the surface of nickel-based alloys, and their corrosion resistance and adhesion, and its corrosion resistance, adhesion, and self-cleaning properties were tested. The experimental results show that the prepared surface has good superhydrophobicity, and its contact angle is 156.8° and the rolling angle is 4.2°. Different laser scanning distances have a significant effect on the wettability of the metal surface. As the scanning distance increases from 5-50 μm, the contact angle changes from 156.8°-121.7°, and the rolling angle changes from 4.2°-90°. Electrochemical corrosion experiments show that when the scanning distance is 15 μm, the corrosion resistance is better improved, and the self-cleaning experiment shows that water droplets can easily take away surface dust. Changing the scanning interval can control the surface morphology to achieve super-hydrophobicity, and effectively improve the surface corrosion resistance.