In this paper, the safety configuration scheme and application of the pressure vessel laser welding production line are studied. According to the process specification of the laser welding production line, the number of main safety station equipment of the pressure vessel production line is configured. According to the requirements of the pressure vessel safety production and lean production, the layout of the welding production line is in the core area of the whole plant with its production process, from left to right. According to the laser welding process, the main laser welding stations are arranged, the auxiliary stations are arranged around the main laser welding stations, and the same process is arranged at the intersection of the conveyor line to reduce the distance of the conveyor line. And the main laser welding station special machine design of the production line, including equipment configuration, the characteristics of each special machine are discussed, including teaching characteristics, structural characteristics, laser welding characteristics and so on. After completing the layout of the whole production line, the workshop has straight and circular green channels, and the conveyor line is divided into cross straight conveyor line and trunk road conveyor line, so that the production is continuous, smooth flow and no stagnation.