By controlling the arrangement of liquid crystal molecules,liquid crystal spatial light modulators (LC-SLM) modulate light through changing external voltage intensity. Recently,the importance of LC-SLM applicable in ultra-violet region continuously increases due to multiple applications such as photo-polymerization 3D printing. However, the vast majority of liquid crystal materials are organic compounds that absorb light and react in ultraviolet band. To expand the application band of liquid crystal materials, this paper designs a class of liquid crystal materials that do not absorb or react to light in the 325~400 nm band by selecting functional groups that do not absorb or react to light in the application band and simulating the ultraviolet-visible spectrum of the liquid crystal materials to verify the rationality of the design. The ultraviolet stability of the liquid crystal materials is compared with that of two common mixed liquid crystal materials after the ultraviolet-resistant liquid crystal compound is configured into a mixed liquid crystal material. After being irradiated by a 325 nm ultraviolet light source for 120 min, the absorbance and phase transition temperature of the liquid crystal material hardly change, the birefringence changes by 0.04%, the threshold voltage changes by 1.39%, and the response time changes by 0.32%.