High frame frequency medium wave refrigerated infrared detectors are widely used in airborne photoelectric pods, infrared warning systems and photoelectric tracking and aiming systems. The traditional medium wave cooling infrared detector of HgCdTe is limited by the integration time, and the frame frequency is generally limited by 25~100 Hz under the premise of ensuring the imaging quality. Moreover, InSb medium wave refrigerated infrared detector has good non-uniformity, low blind element rate and high frame frequency output characteristics, which can further improve the infrared system range and tracking accuracy. In this paper, a high-speed and stable image acquisition system is designed based on InSb medium wave refrigeration infrared detector, and the image output of 640×512 resolution digital video at 200 Hz is achieved. In the high frame frequency mode, the cross-talk between the detector integration time and the readout time signal is solved, and the non-uniformity of infrared image is effectively reduced. The system can further improve the frame frequency through the window setting of the detector, which can realize the infrared detection, search, identification, reconnaissance, intelligence collection, tracking and so on.