In order to improve the service life and performance of TC4 titanium alloy parts, design of multiple laser process parameters using orthogonal test method. Mg-Co alloy coatings were prepared on titanium alloy the surface by laser cladding process. The influences of current, pulse length and scanning speed on the dilution rate and aspect ratio of cladding layers as well as the interactive action among the each influencing factors are analyzed and verification experiments. Finally obtain the best process parameters of the titanium alloy single-track laser cladding. The results show that the scanning speed has the most significant influence on the dilution rate of cladding layer, while the pulse width has the most obvious influence on the aspect ratio of cladding layer. Through the contrast analysis, the best combination of process parameters was obtained, and provide experimental reference for later laser cladding of titanium alloy magnesium-cobalt alloy forming test.