The non-clinical research data in the registration materials of energy therapy products, including dose-effect relationship and energy safety research data, are crucial for evaluating the safety and effectiveness of these products. This paper elucidates the specific requirements for various energy therapy products, such as optics, ultrasound, radiofrequency, and microwave equipment. It defines the concepts of dose-effect relationship and energy safety and proposes detailed requirements for the registration research materials pertaining to these aspects. The aim is to provide assistance and guidance to registration applicants and relevant practitioners in submitting pertinent content materials.