The design and treatment scale of sewage treatment project in an industrial agglomeration area is 3.0×10⁴ m³/d. In view of the characteristics of high proportion of industrial wastewater, large impact load of water quantity and water quality and high requirement of effluent quality, the biochemical treatment system adopts "A²O+MBR" treatment process, which strengthens the biodegradation and achieves the goal of nitrogen and phosphorus removal, thus meeting the requirements of pollutant discharge in the Yellow River Basin of Henan Province. The process design parameters of the main treatment structures are introduced, which can be used for reference by relevant designers.