Chromatic dispersion is a major factor affecting system performance in 160 Gb/s 100 km optical time-division multiplexing (OTDM) communication systems. To reduce the resulting signal waveform distorted, theoretical analysis and research are done, which is verified by the corresponding experiments. Hybrid dispersion compensation is adopted in the transmission link. Chromatic dispersion and chromatic dispersion slope are compensated accurately. The optimized chromatic dispersion map of the transmission link and working power of the various points are optimized. So nonlinear effects are suppressed effectively. The whole system performance is improved by high precision dispersion management. The fiber length is adjusted to the order of 10 m with 500 GHz optical sampling oscilloscope, and the experimental results are observed accurately. Neither the forward error correction technology nor the compensation of polarization mode dispersion(PMD) is used. 100.25 km stable error-free (bit error rate is smaller than 10^{-12}) transmission of 160 Gb/s OTDM signal is achieved through high-precision chromatic dispersion management.