The microstructure and mechanical properties of a 360 MPa grade high-strength cold-rolled double-sided enamel were studied by optical microscope, scanning electron microscope and tensile tester. The fish-scaling resistance of the experimental steel was evaluated by hydrogen penetration experiment, and the wet and electrostatic dry applying experiments were also performed in the laboratory. The results show that the microstructure of the experimental steel before and after enameling is ferrite, the ferrite changes from flat to equiaxed and the average grain size increases from 5.47 μm to 7.07 μm. The precipitates of the experimental steel before and after enameling are mainly composed of C, S, Mn and Ti, and the amount of precipitates in the grain decreases obviously after enamel. Before enameling, the yield strength, tensile strength and elongation of the experimental steel are 382 MPa, 469 MPa and 34.5%, respectively. After enameling, the yield strength reduced to 355 MPa, the tensile strength reduced to 405 MPa, and the elongation increased to 38%. The decrease of the strength is caused by the increase of the average grain size of ferrite and the decrease of the density of the second phase precipitates. The hydrogen penetration time of the experimental steel is 9.68 min. After double-sided enamel by wet and electrostatic dry methods, there is no fish-scaling defect indicating good adherence performance.