Due to the many factors affecting the quality of the laser welding, though there are a lot of process parameters researches on the laser welding, the effective means of the optimization of the process parameters is deficient. Taguchi approach is used as statistical design of experiment(DOE) technique for optimizing the laser welding parameters in this paper. The experiments for laser welding common 304 stainless steel with the Taguchi method is designed. The experiments result is analyzed by signal to noise ratio and ANOVA using the softwares of Minitab14 and Design-expert7. The effects of the parameters of the Nd:YAG pulsed laser on the weld width and the tensile are studied. The mathematical models which can predicted the weld quality(the weld width and the tensile) and optimize the process parameters are developed. As a result, the influences of pulse width and voltage on the weld width are greater than frequence and speed, and the speed and the pulse width play a major role on the tensile, which shows that the mathematical models developed by softwares can predicted the results very well.