Lyotropic Chromonic Liquid Crystals (LCLCs) are a type of lyotropic liquid crystals formed by self-assembly of soluble aromatic compounds. Due to their rich physical anisotropy, biocompatibility, and controllability, LCLCs have important research value in applications such as biosensing, bacterial manipulation, etc. This article reviews the research on performance control of LCLCs, briefly introduces their characteristics, and focuses on the effects of control methods such as director alignment and doping on LCLCs. Finally, feasible control methods and possible future development routes are discussed and summarized.