At present, the main methods for controlling myopia in clinical practice include optical correction, drug treatment, surgery, outdoor activities and so on. Among them, defocus frame glasses in optical correction have advantages such as acceptable myopia control effect, convenient wearing, fewer adverse reactions, and no age limit, and are widely used in clinical practice. This article summarized the control effect and possible mechanism of different design types of defocus frame glasses on myopia, in order to provide reference guidance for the clinical application of defocus frame glasses.