The corrosion of high lithium glass on fused cast zirconia corundum bricks were studied through static and dynamic erosion experiments. The surface composition of cast zirconia corundum bricks after corrosion by high-lithium glass liquid in actual production was tested. So as to correctly find the reasons of the corrosion of high-lithium glass on fused cast zirconia corundum bricks in actual production. The research results show that the lithium element in the raw material seriously erodes the fused cast zirconia corundum brick, which is due to the small lithium ionic radius, low valence, and large diffusion coefficient, which makes it easier to react with the acid oxide SiO2 and amphoteric oxide A12O3 in the fused cast zirconia corundum brick, thus causing erosion.