In order to obtain the visualization and scenarioization effect of laser interference on an infrared imaging system, a simulation system of infrared imaging laser countermeasure was built by using unreal engine. Firstly, the model and scene editing function of unreal engine was used to construct the antagonistic scene and simulate infrared imaging. The mathematical model of laser interference was built to generate the simulation of laser interference spot, and the simulation of different distances, different infrared imaging fields of view, and different laser incident angles were realized. The images before and after the interference were compared and analyzed. The results show that when the infrared imaging field of view remains unchanged, the interference distance decreases from 3.7 km to 2.9 km and 2 km, and the interference distance remains unchanged, the infrared imaging field of view decreases from 8° to 6° and 4°. In both cases, the proportion of interference spot area in imaging gradually increases; When the infrared imaging field of view and interference distance remains unchanged, and the laser incidence angle is adjusted within the range of ±4°, the interference spot area remains almost unchanged. This system can simulate the effect of infrared imaging and laser countermeasures and can be used as a basic tool to evaluate the effectiveness of infrared imaging laser countermeasures.