Blister wounds are featured with over-generated wound exudate and extensive skin peeling, call for breathable temporary skin with effective exudate management, and function as an extracellular matrix to accelerate regeneration of wound skin. Traditional extracellular matrix (ECM) mimicked nanofibrous 3D scaffold and corresponding hydrogel composites suffer from poor mechanical strength, and the wound exudate management behavior is seldom studied. Herein, we proposed the strategy to enhance the mechanical properties of a 3D nanofiber scaffold via constructing a long nanofiber (NF) and sodium alginate (SA) aerogel interpenetrated architecture (NF/SA). The as-prepared scaffold was then evaluated as temporary skin for a full-thickness defect wound. After absorption of blister fluid, the aerogel transferred into a hydrogel and imparted a wet wound care environment with a water-vapor transmission rate of (6 001.90±522.04) g/(m²·24 h), and Young's modulus of (2.97±0.38) MPa. The exudate was continuously refreshed by a directed and dynamic pump, followed by volatilization driven by Brownian motion. Meanwhile, the NF/SA scaffold exhibited decent compatibility with blister fluid. The basic fibroblast growth factor (bFGF)-loaded NF/SA improved the wound healing rate by 36.46% on Day 3 and 15.34% on Day 7 in the full-thickness defect wound model.