In order to obtain the change of posture of moving objects in wind tunnel experiment, a method of single- camera visual pose measurement based on three-dimensional topography model of object surface is proposed. The method uses the multi-perspective imaging principle to solve the target pose, obtains the feature corner point on the target as the characteristic point needed for the solution, and proposes to use target’ s 3D surface topography information to obtain the geometric relationships between feature points. In this paper, the accuracy of the measurement method is verified under the laboratory conditions. The average accuracy of displacement is 0.23 mm and the mean square error is 0.234 mm. The accuracy of the pitch angle, yaw angle and roll angle are 0.08° , 0.1°and 0.09° , respectively, and the mean square error are 0.485° , 0.312° and 0.442° . The experimental results show that the method can be used for practical measurement.