In order to obtain the effect of layup method on the properties and microstructure of graphene-carbon fiber/basalt fiber (GO-CF/BF) hybrid reinforced composites, the finite element simulation was used in this study, and four kinds of GO-CF/BF hybrid reinforced composites with different layup methods, namely C6, B2C4, B4C2 and B6, were respectively investigated from macroscopic and microscopic perspectives. The matrix infiltration and three-point bending were simulated to obtain the matrix infiltration effect and bending strength under different layup methods. Finally, the simulation results were compared with the microstructure and test results, and it can be seen that when the layup method is C6, the volume content of matrix in the materials is the highest, and the bending strength is also the highest, up to 525.31 MPa. Basalt fiber has good fracture toughness and low modulus strength, and because of the low bonding rate between basalt fiber and resin, the matrix infiltration effect of GO-CF/BF hybrid reinforced composite is poor and there are pore defects when the layup method is B6. In addition, when the carbon fiber is brittle fracture failure, the load is gradually transferred to the basalt fiber with lower modulus and stiffness, thus affecting the interface bonding ability between the fiber and the matrix. Based on the above reasons, the bending s trength simultion value of the composite materials with a layup method of B6 is reduced to 115.16 MPa. Combined with the actual test results, it is shown that the finite element simulation is reasonable to predict the infiltration effect and bending strength of GO-CF/BF hybrid reinforced composites.