The non-contact bonding structure can be realized by laser micro-welding, which is suitable for packaging between alloy. In order to improve the comprehensive performance of TA2/316L composite plate with mechanical dynamic connection structure, the high repetition frequency laser welding was used to fabricate it. The joint strength of TA2/316L composite plate was analyzed, and the optimal process parameters of high repetition frequency laser parameters were determined as follows: pulse power 14 μJ, defocus 0 μm, repetition rate 500 kHz, welding speed 0.6 mm/s, and the joint strength could be increased to 8.8 MPa, which promoted the obvious improvement of welding efficiency. The performance of transverse truncation surface in welding zone was analyzed by experimental test. Results show that the molten TA2 penetrates into 316L to produce many pits, and 316L is mixed with TA2. After 316L high repetition laser ablation, high temperature plasma is formed and the surface of TA2 melts, filling 316L ablated micropores. A large number of irregular distribution holes are formed on the side of TA2, and obvious raised packets are generated on the side of 316L. A large number of TA2 covers exist on the surface of 316L, which can closely connect TA2/316L composite plate.