Objective: Investigating the clinical effect of intravascular laser irradiation (ILIB) on subacute CCD after stroke. Methods: From June 2019 to December 2021, 48 patients who suffered from acute stroke and received brain SPECT in our hospital were selected as the study subjects, and were matched into ILIB treatment group (n=24) and conventional treatment group (n=24) according to stroke laterality, gender, infarction, hemorrhage, and other factors. Brain SPECT was performed with 99mTc-hexamethylpropioxime (99mTc-HMPAO) to detect CCD. The functional results were evaluated at 2 time points by the simple mental state examination (MMSE), functional walking category (FAC) and modified Barthel index (MBI). The functional recovery was analyzed to reveal the functional gain of each clinical score (MMSE, FAC, MBI) between the initial and subsequent evaluations. Results: According to independent T-test, there were no significant differences in MMSE, FAC, MBI, MMSE, FAC, and MBI scores in the conventional treatment group at the initial assessment (P values were 0.122, 0.106, 0.125, 0.123, 0.091, and 0.136, respectively). The recovery of FAC was worse in the conventional treatment group (P=0.001), and the mean functional recovery of MMSE and MBI in the conventional treatment group was lower than that in the ILIB treatment group, but there was no statistically significant difference in the recovery of MMSE and MBI between the two groups (P= 0.032 and 0.036, respectively). Conclusion: Intravascular laser irradiation can improve CCD and facilitate functional recovery. ILIB has a good clinical effect on CCD in the subacute stage after stroke.