LCD industrial instrumentation, automobile instrumentation have stricter and stricter requirements for high-temperature working performance. The phenomenon of image missing at high temperature seriously deteriorates the display performance of the product. According to the actual situation encountered in the LCD application, the cause of high-temperature image missing has been studied. Through theoretical analysis and experiments, the reasons for high-temperature image missing are found in three aspects： driving frequency, N-LINE setting, liquid crystal voltage, and impurity ions in the cell. The frequency and N-LINE settings can reduce the effect of the DC component electric field, the liquid crystal voltage can reduce the strong polar molecules, and the less impurity ions in the box can reduce ion accumulation. Through experimental research, the product can meet the requirement of 500 hours work at 70°C without missing. Through parameter optimization, the images missing phenomenon of high-temperature is effectively improved, and the product quality is improved through the improvement, and good economic benefits are achieved.