Sildenafil and tadalafil are often illegally added in healthcare products, and large numbers of related criminal cases were reported in recent years. Therefore, rapid detection of sildenafil or tadalafil is of great significance for the crackdown on related crimes. Compared with laboratory methods, Raman spectroscopy is a simple and low-cost technique. These years, it has been increasingly applied in rapid screening of illegally added drugs in healthcare products. In this manuscript, a method capable of simultaneously detecting sildenafil and tadalafil in healthcare products was established based on surface-enhanced Raman spectroscopy. Using a portable Raman spectrometer, the detection limit reached 5 mg/kg for sildenafil, and 10 mg/kg for tadalafil. This method could detect many types of healthcare products including capsules and tablets within only 10 minutes. The methods developed could be employed by market supervision departments and public security departments, and have broad application prospects in the field of food safety analysis.